Molecular signature characterisation of different inflammatory phenotypes of systemic juvenile idiopathic arthritis

Gohar, F., et al. Molecular signature characterisation of different inflammatory phenotypes of systemic juvenile idiopathic arthritis, Annals of the rheumatic diseases. Volume 78, Number 8, 1107-1113

The International League of Associations for Rheumatology classification criteria define systemic juvenile idiopathic arthritis (SJIA) by the presence of fever, rash and chronic arthritis. Recent initiatives to revise current criteria recognise that a lack of arthritis complicates making the diagnosis early, while later a subgroup of patients develops aggressive joint disease. The proposed biphasic model of SJIA also implies a ‘window of opportunity’ to abrogate the development of chronic arthritis. We aimed to identify novel SJIA biomarkers during different disease phases.

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