Rowland, A., et al. Plasma extracellular nanovesicle (exosome) derived biomarkers for drug metabolism pathways: A novel approach to characterise variability in drug exposure. British Journal of Clinical Pharmacology. 19/10/2018.
Demonstrate the presence of cytochrome P450 (CYP) and UDP-glucuronosyltransferase (UGT) proteins and mRNAs in isolated human plasma exosomes and evaluate the capacity for exosome- derived biomarkers to characterise variability in CYP3A4 activity.