Uncovering changes in proteomic signature of rat pelvic floor muscles in pregnancy, American journal of obstetrics and gynecology

Burnett, L., et al. Uncovering changes in proteomic signature of rat pelvic floor muscles in pregnancy, American journal of obstetrics and gynecology. Volume 221, Number 2, 130e1.130.e9

Structural and functional changes of the rat pelvic floor muscles during pregnancy, specifically, sarcomerogenesis, increase in extracellular matrix content, and higher passive tension at larger strains protect the integral muscle components against birth injury. The mechanisms underlying these antepartum alterations are unknown. Quantitative proteomics is an unbiased method of identifying protein expression changes in differentially conditioned samples. Therefore, proteomics analysis provides an opportunity to identify molecular mechanisms underlying antepartum muscle plasticity.

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