Hooks, J., et al. In-vitro model reveals a role for mechanical stretch in the remodeling response of lymphatic muscle cells. Microcirculation. e12512. 1/11/2018.
LMCs were sensitive to changes in serum levels, significantly reducing overall activity and collagen synthesis under low serum conditions. LMCs from the remodeled vessel had higher baseline levels of metabolic activity but not collagen synthesis. Cyclic loading induced cellular alignment perpendicular to the axis of stretch and alterations in signaling pathways associated with metabolism. Remodeled LMCs had consistently higher levels of metabolic activity and were more resistant to strain induced apoptosis.