We're excited to join the 15th Asian Community of Glycoscience and Glycotechnology (ACGG) conference, held jointly with the 7th Australasian Glycoscience Symposium, October 3–6. This meeting brings together researchers from across the Asia-Pacific glycoscience community, and we're looking forward to the conversations.

Dates: Oct 3rd - 6th, 2026
Venue: Common Auditorium of AIST Tsukuba Central, Tsukuba, Japan

We are excited to announce our company talk during the Glycobioinformatics Session!

Bridging Database Search and Full De Novo Sequencing for Unbiased Glycopeptide Identification

Date/Time: Oct 6th; 13:00-13:20
Location: Main Hall

Glycopeptide identification is often limited by the glycan database behind it. However, our glycoproteome solution goes further! We demonstrate how combining database search with glycopeptide 𝘥𝘦 𝘯𝘰𝘷𝘰 sequencing improves identification accuracy and uncovers glycopeptides that database-only approaches miss, especially when the glycan database is incomplete.

If you're attending, stop by our presentation and let's talk glycoproteomics. We look forward to connecting with everyone in Tsukuba!

Learn more and register here: https://j-lppf2.jp/acgg2026th/

A recent paper published in Neuron, from Weill Cornell Medicine and collaborating institutions, highlights that surgical removal of cervical lymph nodes may disrupt the brain's waste clearance, with consequences for cognitive health.

Khan, Clement et al. analyzed records from head and neck cancer patients who underwent neck lymphadenectomy without chemo-radiation. Up to 18% of patients under 65 developed mild-to-severe cognitive impairment within two years, three to four times the expected rate, and 25% did in those 65 and older. MRI showed faster temporal horn widening after bilateral surgery (17% per year) than unilateral surgery (4.2% per year).

To investigate the mechanism, the team modelled abrupt lymphatic disruption in mice and rats. Cerebrospinal fluid showed a signature of metabolic stress and mild inflammation, including activation of NAD⁺ and glutathione synthesis pathways. In the hippocampus, redox stress drove oxidative post-translational modifications and the formation of protein microaggregates. These were enriched in presynaptic and mitochondrial proteins, suggesting that synaptic regions are especially vulnerable to waste-induced stress.

PEAKS Studio and PEAKS Online were used for database searching and TMT-based quantification (PEAKS Q) of the CSF proteome, and for label-free quantitation of the 880 proteins identified in the isolated microaggregate fraction. PEAKS' PTM search capabilities were used to identify oxidative and glycation-related modifications and ubiquitination sites on the aggregated proteins, linking redox imbalance to protein damage at the site level. PEAKS Online was also used to analyse hippocampal DIA-PASEF data, enabling deep, label-free profiling of hippocampal tissue from ligated and sham mice, revealing 72 differentially expressed proteins

The aggregates differed in composition and modification profile from those seen in Alzheimer's disease and were absent when lymphatic drainage was reduced gradually. These findings link cognitive impairment after acute neck lymphadenectomy to impaired metabolic waste clearance. BSI is proud to see PEAKS support research that connects clinical observations to molecular mechanisms.

Read the full article here: Khan, Z.N., Clement, C.C., Roßmüller, P., …, Benveniste, H., Kipnis, J., Santambrogio, L. (2027) Cervical lymphadenectomy impairs brain lymphatic clearance and synaptic proteostasis. Neuron 115. doi:10.1016/j.neuron.2026.09.005

BSI is sticking around in Singapore to attend the HUPO World Congress 2026!

The BSI team is excited to be back on the ground for the HUPO World Congress (Sept 27 – Oct 1), and this year we're bringing a full showcase of what's new across PEAKS Software and our Lab Services!

Dates: Sept 27^th - Oct 1^st, 2026
Venue: Suntec Singapore Convention & Exhibition Centre

Stop by Booth 236 to:

See what's new in PEAKS — the latest features and updates across our proteomics software suite.

Learn how our Lab Services team can support your project from sample to results, end-to-end.

Meet the Scientists and Developers behind the tools, and Explore your research challenges together!

Be sure to catch our Poster Presentations as well! We’ll be showcasing some great new research!

Title: Positive-Unlabeled Learning Enables More Accurate Peptide Identification
Date/Time: Monday, Sep 28, 2026, 1:15 PM - 3:00 PM
Location: Exhibit Hall

Whether you're deep in discovery proteomics, tackling immunopeptidomics data, or just curious what PEAKS can do for your workflow — our team will be at Booth 236 all week.

Come say hi, we’d love to chat!

Learn more and register here: https://2026.hupo.org/

BSI is heading to HIPP-HUPO Summer School 2026!

We're excited to announce that BSI will be exhibiting at the HIPP-HUPO Summer School, taking place Sept 23rd-26th in beautiful Singapore! Stop by our booth to connect with our team and see firsthand how PEAKS Software and our Lab Services are supporting proteomics research worldwide.

Dates: Sept 23rd – 26th, 2026
Venue: RELC International Hotel, Singapore

Explore PEAKS Software and our Lab Services!
At our booth, you'll get a look at the latest advances in our PEAKS platforms for proteomics, peptidomics, and more, along with our growing suite of Lab Services — including DeepImmu, our comprehensive solution for identifying and characterising antigens specifically displayed on infected cells or tumours. Whether you’re working on immunopeptidome discovery, PTM characterization of HLA peptides, or sequence variant analysis, our scientists will be on-site and ready to talk through your research needs!

Be sure to catch our talk!
We're also proud to be presenting a talk, exploring how our team is tackling the speed and complexity challenges that come with characterizing immunopeptidomes and HLA-bound modified peptides.

Title: Precise, fast and comprehensive analysis of immunopeptidome and modified HLA peptides with PEAKS
Session: Thursday, Sept 24th : 14:00

Let's connect. We'd love to hear about your work and discuss whether our PEAKS Software or Lab Services could be a good fit for you.

We look forward to seeing everyone in Singapore!

Learn more and register for the conference here: https://hupo-hipp-summer-school.mailchimpsites.com/

Join us for our PEAKS Proteomics Workshop at UC San Diego!

Register for the Workshop!

October 23rd, 2026 | 12:00 PM - 5:30 PM | UC San Diego

Explore new approaches to PEAKS data analysis and discover ways to tackle challenging proteomics datasets with greater confidence. The workshop will showcase applications across peptide identification, PTM and sequence variant analysis, immunopeptidomics, and large-scale proteomics.

Designed for both new and experienced PEAKS users, the afternoon will combine focused sessions with opportunities for discussion and knowledge exchange with researchers from across the San Diego proteomics community.

Topics:

• Discover More with PEAKS Exclusive de novo-assisted and DDA Analysis
• Streamline DIA Analysis from Identification to Quantification
• Explore Beyond Conventional - PTM, Open PTM, and Sequence Variant Depth
• Unlock Deeper Immunopeptidome Insights with Dedicated DeepNovo-driven Algorithms
• Scale with Confidence: Large-Cohort Analysis & Real-Time QC

Refreshments will be provided!

Registration is open to everyone and Free! In-person attendance is required.

Sign Up Below!

BSI is heading to CASSS Mass Spec 2026 conference this week!

Date: Sept 16^th-18^th
Venue: Hilton Washington DC/Rockville Hotel, Rockville, Maryland
Booth No: 13

Stop by 𝗕𝗼𝗼𝘁𝗵 𝟭𝟯 to connect with the BSI team and learn about the latest advances in our 𝗣𝗘𝗔𝗞𝗦 platform, as well as our brand-new 𝗟𝗮𝗯 𝗦𝗲𝗿𝘃𝗶𝗰𝗲𝘀 tackling multispecific antibody characterization and more!

Don't miss our poster: "𝗘𝘃𝗮𝗹𝘂𝗮𝘁𝗶𝗻𝗴 𝗖𝗿𝗶𝘁𝗶𝗰𝗮𝗹 𝗤𝘂𝗮𝗹𝗶𝘁𝘆 𝗔𝘁𝘁𝗿𝗶𝗯𝘂𝘁𝗲𝘀 𝗼𝗳 𝗠𝘂𝗹𝘁𝗶𝘀𝗽𝗲𝗰𝗶𝗳𝗶𝗰 𝗔𝗻𝘁𝗶𝗯𝗼𝗱𝗶𝗲𝘀 𝗯𝘆 𝗠𝘂𝗹𝘁𝗶-𝗟𝗲𝘃𝗲𝗹 𝗠𝗮𝘀𝘀 𝗦𝗽𝗲𝗰𝘁𝗿𝗼𝗺𝗲𝘁𝗿𝘆", showcasing how our integrated MS-based approach tackles correct pairing, PTM/glycan analysis, sequence validation, and more.

𝗧𝗶𝘁𝗹𝗲: Evaluating Critical Quality Attributes of Multispecific Antibodies by Multi-Level Mass Spectrometry
𝗦𝗲𝘀𝘀𝗶𝗼𝗻𝘀: Wed, Sept 16: 9:45 AM – 10:45 AM; Thurs, Sept 17: 9:45 AM – 10:15 AM
𝗣𝗼𝘀𝘁𝗲𝗿 𝗻𝗼: 115

Come say hi, we would love to learn more about your research and see if our PEAKS software or lab services could be good fit!
See you in Rockville, Maryland!

Learn more and register here: https://www.casss.org/mass-spectrometry

A recent paper in Nature, from the Church Lab at Harvard Medical School & the Wyss Institute introduces AGENTEX (automated genetic tRNA expansion), a robotic, multiplexed tool for building and testing new genetic codes in cell-free translation systems.

Radford et al. revisited a long-standing assumption that the tRNA 3′ CCA end, where amino acids attach and tRNAs dock into the ribosome, must be intact for aminoacylation. Using a new sequencing method they developed, tSCAN, the team varied the tRNA 3′ end across the entire E. coli tRNA set and found that most non-CCA tRNAs ("otRNAs") were still efficiently charged by natural synthetases, far more tolerant to mutation than previously believed.

Building on this, the authors engineered ribosomes (G2251C/G2553C, "CGA ribosomes") that specifically accommodate otRNAs while ignoring native tRNAs. Pairing otRNA pools with these orthogonal ribosomes gave rise to AGENTEX, run end-to-end on an automated OT-2 robotic platform. Using it, the team compressed the 64-codon code down to as few as 21–22 codons, incorporated a non-standard amino acid via amber suppression, and showed the compressed and standard genetic codes could run in parallel, without "crosstalk". Confirming this "zero crosstalk" required proteomics sensitive enough to catch rare mistranslation events. The team relied on PEAKS Studio 13 to search high-sensitivity LC-MS/MS data against custom libraries covering every possible amino acid substitution their engineered codes could introduce, showing that the ribosome, not the synthetase, is the real gatekeeper of genetic code fidelity.

Congratulations to the Church Lab on this remarkable accomplishment! This breakthrough technology overturns decades of understanding of how transfer RNAs (tRNAs) help turn the genetic code into proteins and takes a leap forward by making 34 codons customizable, allowing researchers to make proteins with up to 34 different amino acids much faster and safer.

BSI is delighted to witness the application of PEAKS software in this pioneering research within synthetic biology! We sincerely appreciate our ongoing collaboration with Dr. Bogdan Budnik and look forward to future advancements.

Read the full article here: Radford, F., Sapers, N., Burgess, H. M., Ort, L., Budnik, B., & Church, G. M. (2026) Automated prototyping of genetic codes. Nature. https://doi.org/10.1038/s41586-026-10949-y

Date: August 23^th–25^th, 2026
Venue: Centre des Congrès de Lyon, France
Booth No: 48

We're excited to announce that BSI will be at the International Mass Spectrometry Conference (IMSC) 2026 in beautiful Lyon, France! Come find us at Booth 48!

This year, we're showcasing exciting new improvements to our platforms, designed to help you work smarter, faster, and with even greater precision. Our team will be on hand throughout the event to walk you through what's new, answer your questions, and talk about how these updates can support your research and workflows.

Whether you're a longtime partner or just discovering BSI, we'd love to connect. Stop by to see the latest in PEAKS firsthand and chat with our team!

We can't wait to see you in Lyon!

Learn more and register here.

PEAKS^® Online 13.5 introduces redesigned DDA and DIA workflows for streamlined and user-friendly experience with enhanced algorithms. With a fresh UI, increased data and system stability, and simplified parameter selection users can take their analyses to new heights! CFR compliance readiness ensures data integrity, security, and audit preparation in any clinical or industrial setting!

Exclusive to PEAKS Online 13.5 are the Automated Large-Cohort and Real-time Quality Control workflows, providing a comprehensive interface for automated instrument-to-software data processing and real-time quality assessment.

Automated Large-Cohort Analyses

PEAKS Online 13.5 delivers an automated, real-time proteomics data analysis pipeline with instrument monitoring, streamlined data processing, and an accumulative results overview to accelerate QC and exploration of large-cohort datasets.

Real-time Quality Control

Exclusive to PEAKS Online, this pioneering workflow incorporates Instrument Daemon functionality for automated screening of QC samples. The streamlined workflow enables immediate assessments of technical variation throughout acquisition, and users are notified immediately if QC attributes fail to meet the defined standards.

Open PTM Search

PEAKS' Open PTM Search algorithm delivers an efficient, sensitive, and unbiased solution for characterising unknown PTMs, supporting a wide range of experimental setups, including various digestion modes and isotopic labelling.

Ready to see what’s possible with Online 13.5?
Check out the full list of features and enhancements on our launch page.

Discover faster insights, deeper results, and more flexibility than ever before.

The PEAKS Team
Bioinformatics Solutions Inc.

Date: June 23^th–25^th, 2026
Venue: Westin San Diego Bayview, San Diego, CA, USA
Booth No: 6

We are headed back to sunny San Diego, to attend the 8th Annual T-Cell Engager Therapeutics Summit—and we're coming with a lot to share!

Join us at Booth 6 as we showcase the latest advancements in our PEAKS software platforms, available for various proteomics workflows. Hear from our experienced team members about how our advanced lab solutions are providing deeper insight to researchers. Don't miss our poster presentation as our talented Applications Manager, Kyle Hoffman, will also be talking about our new developments to our lab services methodologies.

Whether you're deep into bispecific development or just curious about what's new in proteomics, we'd love to connect and talk science!

Learn more and register here.