HUPO 2021 (November 15 – 19, 2021)

Bioinformatics Solutions Inc. is proud to be a sponsor of the 20th annual HUPO World Congress: HUPO 2021 ReCONNECT.

Learn about our latest research and our advanced deep learning enabled DIA Workflow integrated into PEAKS Online Xpro when you join us on Gather.town during HUPO ReCONNECT 2021. As experts in de novo sequencing, we always wanted to adventure beyond a protein database. Let the PEAKS team now help you advance past a peptide spectral library with truly unbiased discovery proteomics!

Highlights of PEAKS Online Xpro:

  • Go beyond with unbiased discovery
    New identification workflow that combines spectral library search, database search, and de novo sequencing to provide an in-depth analysis.
  • Deep learning enabled
    PEAKS Online Xpro uses deep learning based technology for prediction of spectra, rt and ccs values. This new technology helps gain access to the low abundance peptides.
  • Data analysis is now faster than data acquisition time!
    Receive PEAKS’ sensitivity and accuracy at a much faster pace. Accelerate your data analysis time with GPU and clustered based solutions.
  • Comprehensive result visualisation
    To fully interrogate your data and results, you need a solution that allows you to visualize and validate your analysis. From spectra to peptide to protein, PEAKS Online can support large-scale projects and still allow you to fully dive into your analysis to the finest detail.
  • Easy to use
    With saved User workflows or just few clicks with default parameters, users can start analysis with ease and receive an email notification once task has completed.

As experts in de novo sequencing, we know the importance of going beyond a protein database. Let the PEAKS team now help you advance past a peptide spectral library with truly unbiased discovery proteomics!

Virtual Industry-Supported Seminar

Furthering the Understanding of the Human Proteome Using New MS-Based Workflows
Date: Monday, November 15th
Time: 16:15 – 17:15 (EST) / 21:15 – 22:15 UTC

Chair: Zac Anderson, Bioinformatics Solutions Inc.
Presenters: Curtis McMurtrey, Ph.D., PureMHC; Dan Maloney, Bioinformatics Solutions Inc.; and Zia Rahman, Bioinformatics Solutions Inc.

Description: 

For biomarker discovery in oncology and clinical research, mass spectrometry(MS)-based proteomics is a proven technique to systematically identify and quantify peptides/proteins in a biological sample. As technologies advance, subfields like Immunopeptidomics and Glycoproteomics, require innovative approaches and powerful data analysis solutions. To answer to developments in these fields. we hope to contribute to furthering the understanding of the Human Proteome using new MS-based Workflows and developing advanced bioinformatic tools.

On November 15th, 2021, we are happy to have Dr. Curtis McMurtrey, Director of Immuno-Proteomics at Pure MHC, LLC and two core members of our BSI team, Dan Maloney, Application Scientist, and Zia Rahman, VP of Production, share some of their work.

In the first portion of our talk, Dr. Curtis McMurtrey will present his HLA immunopeptidome workflow at Pure MHC. Immunopeptidomics has become a field of interest in oncology as identification of tumor specific HLA peptide complexes have enabled novel immunotherapies. By using both DDA and SWATH LCMS to characterize the HLA-A02:01 immunopeptidome of primary tumors and normal tissue. Then, by comparing the immunopeptidome of tumors from multiple cancer indications to a large panel of normal tissues representing tissues from the entire human body, their team find only a handful of non-mutated tumor-specific HLA-A02:01 peptides. While these findings do indicate specific peptides, a small subset of tumor-specific HLA peptides are presented across different cancer indications, making these peptides broadly applicable targets for future immunotherapies.

Following, Dan Maloney of BSI, will be presenting a brand new deep learning-based solution to DIA with a streamlined workflow for peptide identification. This new identification workflow that combines spectral library search, database search, and de novo sequencing to provide an in-depth analysis. The unique DIA workflow provides spectral library search, an innovative bi-directional database search and PEAKS’ de novo sequencing in a single, easy to use pipeline.

Finally, we are excited to have Zia Rahman, VP of Production at BSI, present some of our latest research work for Glycoproteomics and a sneak peek at the next generation of PEAKS Studio. This new tool created by the BSI research and development teams is called PEAKS GlycanFinder and will serve as a comprehensive Glycoproteomic tool for Glycan Identification and Profiling.

Note: This presentation was approved by the Program Committee as an independent activity held in conjunction with the HUPO Connect 2021. This presentation is not sponsored or endorsed by HUPO Connect 2021.

Brochures and Resources

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