To understand the functions of individual proteins in complex biological systems, it is often necessary to measure changes in protein abundance. For example, Biomarker discovery and validation studies typically require quantitative analysis of proteins to identify and verify potential biomarkers that show protein expression changes significantly between different states/conditions. PEAKS Q allows the scientist to determine relative protein abundance changes across a set of samples simultaneously by labelling or label-free quantification using LC-MS/MS.
- Yang, W., et al. PEAKS Q: Software for MS-based quantification of stable isotope labeled peptides. ASMS. WP531. 30/5/2006.
- Xin, L. et al. New Quantitation Software Package Based on PEAKS Protein ID. ASMS. TP 653. 2/6/2008.
- Chen, C., et al. New Algorithm for Label-Free Protein Quantification. ASMS. MPB 043. 31/05/2009.
- Analyzing TMT PRO 16-PLEX Data in PEAKS Software [Download PDF]