The link between gut & brain health is a target of interest for Parkinson’s disease (PD) research. In this paper, Gordevicius et al, use multi-molecular methods to study PD pathology from epigenetic changes in DNA & altered transcription, to the resulting modified protein abundance.
In vitro metabolism of synthetic Elabela/Toddler (ELA-32) peptide in human plasma and kidney homogenates analyzed with mass spectrometry and validation of endogenous peptide quantification in tissues by ELISA
Studies about cardiovascular diseases have shown the Elabela/Toddler (ELA) ligand to be a beneficial apelin Rc. agonist. In a recent paper, Nyimanu et al. used LC-MS/MS methods to examine how the different forms of ELA individually impact signaling networks in the human body.
A complete workflow for discovering small bioactive peptides in foods by LC-MS/MS: A case study on almonds
In our food and supplements, we see new functional foods and nutraceuticals with new claims everyday. But do these compounds show any bioactivity to support these claims? Huang et al show Mass spec can be a great tool to study these compound.
Monitoring the M-protein of multiple myeloma patients treated with a combination of monoclonal antibodies: the laboratory solution to eliminate interference
In this study, Noori et al show that MS-based MRD monitoring is over 15-fold more sensitive than conventional diagnostic measures. More importantly, MS-based MRD monitoring with PEAKS de novo sequencing can be used with heterogeneous patient populations, and does not have to be adapted when novel t-mAb are approved for use in patients.
A novel nonapeptide SSDAFFPFR from Antarctic krill exerts a protective effect on PC12 cells through the BCL-XL/Bax/Caspase-3/p53 signaling pathway
Zheng, Jingru, et al. “A Novel Nonapeptide SSDAFFPFR from Antarctic Krill Exerts a Protective Effect on PC12 Cells through the...
Cell affinity screening combined with nanoLC-MS/MS based peptidomics for identifying cancer cell binding peptides from Bufo Bufo gargarizans
Wang, Jiaojiao, et al. “Cell Affinity Screening Combined with NanoLC-MS/MS Based Peptidomics for Identifying Cancer Cell Binding Peptides from Bufo...
Biorefinery of exhausted olive pomace through the production of polygalacturonases and omega-3 fatty acids by Crypthecodinium cohnii
Paz, Alicia, et al. “Biorefinery of Exhausted Olive Pomace through the Production of Polygalacturonases and Omega-3 Fatty Acids by Crypthecodinium...
Identification of urinary peptides associated with allergic rhinitis
Liu, N., et al. “Identification of Urinary Peptides Associated with Allergic Rhinitis.” Revue Française d’Allergologie, Elsevier BV, Aug. 2021. Crossref,...
Integrated Phosphoproteomics for Identifying Substrates of Human Protein Kinase A (PRKACA) and Its Oncogenic Mutant DNAJB 1 -PRKACA
Karamafrooz, Adak, et al. “Integrated Phosphoproteomics for Identifying Substrates of Human Protein Kinase A (PRKACA) and Its Oncogenic Mutant DNAJB1–PRKACA.”...
Development of a Freshness Assay for Royal Jelly Based on the Temperature- and Time-Dependent Changes of Antimicrobial Effectiveness and Proteome Dynamics of Royal Jelly Proteins
Hu, Han, et al. “Development of a Freshness Assay for Royal Jelly Based on the Temperature- and Time-Dependent Changes of...