Understanding the constitutive presentation of MHC class I immunopeptidomes in primary tissues

CD8+ T cells can eradicate abnormal cells through the recognition of small peptides presented by major histocompatibility complex (MHC) class I molecules. In this study, a system-level and cross-species analysis of the MHC-I immunopeptidome was conducted to understand how the MHC-I immunopeptidome is being shaped in different primary tissues in vivo.

Betaine Supplementation Causes an Increase in Fatty Acid Oxidation and Carbohydrate Metabolism in Livers of Mice Fed a High-Fat Diet: A Proteomic Analysis

The liver is the main venue for β-oxidation of fatty acids, and it maintains the balance of fat metabolism. Many studies showed that betaine regulates fat metabolism. In this work, the researchers investigated the protein metabolic profile in the liver of mice on an HF diet supplemented with 1% betaine by label free quantification analysis via LC–MS/MS.

The effect of steam cooking on the proteolysis of pacific oyster (Crassostrea gigas) proteins: Digestibility, allergenicity, and bioactivity

The Pacific oyster is a major seafood around the world and it is important to understand the effect of heating on proteins of this aquatic species. Learn how LC-MS/MS was used and how studies on food processing can improve the safety of food and reduce health-related costs.

Cyclic immonium ion of lactyllysine reveals widespread lactylation in the human proteome

Lactylation is a post translation modification (PTM) derived from lactate and here, researchers have shown that lactylation is a widespread PTM that is not restricted to histones and have developed a sensitive and validated method for lactylation identification by liquid chromatography–tandem mass spectrometry (LC–MS/MS).

Proteomic analysis of Exosomes derived from the Aqueous Humor of Myopia Patients

Though there appears to be both genetic and environmental factors that influence the development of Myopia or nearsightedness, the precise mechanism remains unknown. In this study the research group aimed to analyze the exosomal protein profile of the aqueous humor (AH) of myopia patients to provide insight for the diagnosis, clinical treatment and prognosis of myopia.