Proteomic analysis of Exosomes derived from the Aqueous Humor of Myopia Patients

Though there appears to be both genetic and environmental factors that influence the development of Myopia or nearsightedness, the precise mechanism remains unknown. In this study the research group aimed to analyze the exosomal protein profile of the aqueous humor (AH) of myopia patients to provide insight for the diagnosis, clinical treatment and prognosis of myopia.

A Novel Angiotensin-I-Converting Enzyme (ACE) Inhibitory Peptide from Takifugu flavidus

High blood pressure is a common chronic medical condition and a major risk factor in developing cardiovascular disease. The angiotensin-I-converting enzyme (ACE) plays a critical role in controlling blood pressure, and ACE inhibitors are a class of medication in use to treat high blood pressure. Learn how Su et al., studied marine organisms, Takifugu flavidus, to reveal a novel ACE inhibitory peptide.

CPEB1 directs muscle stem cell activation by reprogramming the translational landscape

Understanding what causes a stem cell to enter the cell cycle, and what happens when it does, is key to determining how we can maximise the therapeutic potential of these cells to repair injured tissues or treat diseases. Here, Zeng et al., use LC-MS/MS to study the activation of a particular type of stem cell, Satellite cells (SC), that have the potential to repair damaged skeletal muscle.

Validation of Trifluoromethylphenyl Diazirine Cholesterol Analogues As Cholesterol Mimetics and Photolabeling Reagents

In a recent article by Krishnan et al., researchers use middle-down proteomics to assess different cholesterol mimetics as photolabeling reagents to evaluate protein-protein interactions in situ. This study demonstrates the use of PEAKS Studio for analyzing middle-down data and identify where the various mimetics bound to their model protein Gloeobacter ligand-gated ion channel.

Disturbed mitochondrial acetylation in accordance with the availability of acetyl groups in hepatocellular carcinoma

Acetylation is an important post-translational modification (PTM) and can affect protein activity with a wide range of effects. In a study by Hu and colleagues, demonstrates the utility of global analysis tools, like proteomics for studying complex disease states, to explore the link between acetylation and metabolism in the tumor microenvironment.

Influence of surface termination of ultrananocrystalline diamond films coated on titanium on response of human osteoblast cells: A proteome study

Cell-based assays can be a useful tool for predicting the biocompatibility of different materials used for medical implants. In a recent study Merker et al. assessed the proteome of osteoblasts involved in transplant integration to further understand how these integral processes can be optimised to increase the chances of successful integration.