Learn how PEAKS was used to identify phosphorylation sites Bovine α-lactalbumin (BLA) and how this can effect allergic reaction of BLA.
Learn how the researchers reported two novel families of non-canonical tRNAs, encoded by bacteria from the Streptomyces and Kitasatospora genera, that can induce mistranslation of the genetic code. These results expand the catalogue of organisms known to possess dedicated mistranslation and support the concept that mistranslation is a mechanism for increased cellular resiliency against environmental stress.
The prognosis of rheumatoid arthritis (RA) patients heavily depends on the early diagnosis and aggressive treatment, but current diagnosis cannot occur until the disease has progressed significantly. Learn how human serum albumin structure could potentially be used as a diagnostic biomarker for RA and how the molecular mechanism behind these modifications could lead to the development of new therapeutic strategies.
The glucose-dependent insulinotropic polypeptide is secreted from enteroendocrine cells and can enhance the release of insulin from pancreatic cells. The identification of peptides in human plasma are a challenging task and is barely studied by the scientists. Learn about this novel technology that can improve the plasma extraction yield, leading to the identification of trace peptides with low molecular weight using a single drop of plasma sample.
For MS-based immunopeptidomics, major histocompatibility complex (MHC) peptides are typically isolated by immunoaffinity purification using specific anti-MHC antibodies. In this work, restricted access material (RAM)-SPE (solid-phase extraction) to increase the number of identified MHC peptides compared to C18-SPE.
Listeria is a foodborne pathogen that can cause listeriosis, which can be dangerous specially among vulnerable individuals including immunocompromised individuals. Learn how this study extended the antigen knowledge on Listeria, by applying an immunopeptidomics study on two infected human epithelial cell lines.
Covalent antibody recruiting molecules are synthetic bifunctional molecules capable of inducing antibodies to recognise and eliminate cancer cells by the innate immune machinery. Learn more about this proof-of-concept research by McCann et al, and how a “covalent immune proximity-induction” strategy may enable the efficient recruitment of immune receptors via the incorporation of available modest affinity peptide ligands.
Bottom–up mass-spectrometry-based proteomics is a well-developed technology but the gradient type and time can have influence on the results and must be well studied. Learn how Wei et al. investigated various gradient types, and gradient lengths with different sample loading amounts and loading conditions to optimise the LC step.
Hypertension affects over a billion people around the world and overactivation of renin−angiotensin−aldosterone system (RAS) is one of the main pathologies. Here, this study aims to investigate the effects and mechanisms of bovine bone gelatin-derived peptides (BGPs) on hypertension and hypertension complications.