Mistranslation of the genetic code by a new family of bacterial transfer RNAs

Learn how the researchers reported two novel families of non-canonical tRNAs, encoded by bacteria from the Streptomyces and Kitasatospora genera, that can induce mistranslation of the genetic code. These results expand the catalogue of organisms known to possess dedicated mistranslation and support the concept that mistranslation is a mechanism for increased cellular resiliency against environmental stress.

Modification of the structural stability of human serum albumin in rheumatoid arthritis

The prognosis of rheumatoid arthritis (RA) patients heavily depends on the early diagnosis and aggressive treatment, but current diagnosis cannot occur until the disease has progressed significantly. Learn how human serum albumin structure could potentially be used as a diagnostic biomarker for RA and how the molecular mechanism behind these modifications could lead to the development of new therapeutic strategies.

GIP_HUMAN[22–51] is a new proatherogenic peptide identified by native plasma peptidomics

The glucose-dependent insulinotropic polypeptide is secreted from enteroendocrine cells and can enhance the release of insulin from pancreatic cells. The identification of peptides in human plasma are a challenging task and is barely studied by the scientists. Learn about this novel technology that can improve the plasma extraction yield, leading to the identification of trace peptides with low molecular weight using a single drop of plasma sample.

Extending the Mass Spectrometry-Detectable Landscape of MHC Peptides by Use of Restricted Access Material

For MS-based immunopeptidomics, major histocompatibility complex (MHC) peptides are typically isolated by immunoaffinity purification using specific anti-MHC antibodies. In this work, restricted access material (RAM)-SPE (solid-phase extraction) to increase the number of identified MHC peptides compared to C18-SPE.

Covalent Immune Proximity-Induction Strategy Using SuFEx-Engineered Bifunctional Viral Peptides

Covalent antibody recruiting molecules are synthetic bifunctional molecules capable of inducing antibodies to recognise and eliminate cancer cells by the innate immune machinery. Learn more about this proof-of-concept research by McCann et al, and how a “covalent immune proximity-induction” strategy may enable the efficient recruitment of immune receptors via the incorporation of available modest affinity peptide ligands.

A Comprehensive Study of Gradient Conditions for Deep Proteome Discovery in a Complex Protein Matrix

Bottom–up mass-spectrometry-based proteomics is a well-developed technology but the gradient type and time can have influence on the results and must be well studied. Learn how Wei et al. investigated various gradient types, and gradient lengths with different sample loading amounts and loading conditions to optimise the LC step.

Bovine Bone Gelatin-Derived Peptides: Food Processing Characteristics and Evaluation of Antihypertensive and Antihyperlipidemic Activities

Hypertension affects over a billion people around the world and overactivation of renin−angiotensin−aldosterone system (RAS) is one of the main pathologies. Here, this study aims to investigate the effects and mechanisms of bovine bone gelatin-derived peptides (BGPs) on hypertension and hypertension complications.