Betaine Supplementation Causes an Increase in Fatty Acid Oxidation and Carbohydrate Metabolism in Livers of Mice Fed a High-Fat Diet: A Proteomic Analysis

The liver is the main venue for β-oxidation of fatty acids, and it maintains the balance of fat metabolism. Many studies showed that betaine regulates fat metabolism. In this work, the researchers investigated the protein metabolic profile in the liver of mice on an HF diet supplemented with 1% betaine by label free quantification analysis via LC–MS/MS.