Smarter Workflows, Deeper Discovery.
We are proud to introduce PEAKS GlycanFinder 3.5, the latest evolution of our glycoproteomics and glycomics software platform. This release brings powerful new features and workflow improvements to take your research to the next level.
Glycan de novo-assisted Database search
PEAKS GlycanFinder exclusive glycan de novo sequencing-assisted database search workflow integrates glycan de novo and glycopeptide database search, delivering superior sensitivity of glycopeptide identifications while allowing for the discovery of hidden glycopeptides. Evaluating each MS2 spectrum with two independent approaches results in enhanced confidence and increased glycoproteome depth. Both composition and structure based resolution is available.
Glycan de novo
Novel Glycan de novo workflow allows for glycopeptide deciphering and the analysis of both unknown proteins & unknown glycans. It takes advantage of both peptide backbone and glycan sequencing, allowing users to analyse unknown proteins and glycans. Here an example is shown of a novel glycan identified by our glycan de novo function, which was absent from the database.
Glycosylated Peptidome
A specialised and unique workflow for the discovery and characterisation of completely novel glycan profiles for HLA peptides, without any need for a glycan database. For example, PEAKS GlycanFinder was to able to discover an N- glycosylated peptide as a putative biomarker for drug responses (Phenomics. 1(6):269-284. (2021)).
InChorus—Cross Engine Consensus Results
Our improved InChorus feature combines results from multiple glycan search engines, highlighting both consensus and unique glycopeptide findings. This tool extracts glycoPSMs from external search engine result outputs, visualises spectrum level overlaps for each PSM, and provides a Consensus score - metric that evaluates the consistency and confidence of G-spectral matches across multiple search engines.
Ready to see what’s possible with PEAKS GlycanFinder 3.5?
Check out the full list of features and enhancements on our launch page.
Discover faster insights, deeper results, and more flexibility than ever before.
The PEAKS Team
Bioinformatics Solutions Inc.