ProteoformX 1.5 is Here!
We are excited to introduce the latest update to ProteoformX, bringing enhanced integration between Intact Mass, Top-down and Bottom-up data, with enhanced features for result visualisation and validation. Brand new features including New Peak Detection and Peptide Mapping deliver deeper proteoform insight with greater accuracy, speed, and confidence! CFR-compliance readiness ensures data integrity, security, and audit preparation in any clinical or biopharmaceutical setting.
Top-Down Search
- Achieve a comprehensive understanding of individual proteoforms by integrating Top-down and Bottom-up data analysis to balance broad screening with precise molecular detail, enabling confident sequence validation and resolution of PTM co‑occurrence.
- Verify the safety and efficacy of complex biological systems, including monoclonal antibodies, antibody mixtures, and bispecific formats.
Intact Mass Analysis
- Perform accurate deconvolution with detailed annotations of glycoforms and PTMs to report detectable proteoforms with their corresponding mass and retention time information.
- Explore versatile visualizations options, such as Heat Map view displaying the intensity changes of the selected proteoforms. Use Proteoform Manager to define proteoform details, including residue properties and modifications.
New Peak Detection
- Detect emerging peaks and unexpected components, and monitor variation trends of biopharmaceutical metabolites and product-related contaminants during drug development.
- Effortlessly analyse peptides with unnatural amino acids and nucleotides, as well as branched and cyclic peptides to support the growing complexity of biotherapeutics.
Peptide Mapping
- Use Bottom-up proteomics to characterize protein sequences, post-translational modifications, and sequence variants at the peptide level.
- Take advantage of state‑of‑the‑art algorithms to overlay multiple digest datasets for superior sequence coverage, improved confidence, and enhanced PTM and mutation localisation.
Ready to see what’s possible with ProteoformX 1.5?
Check out the full list of features and enhancements on our launch page.
Discover deeper insights, versatile visualisations, and comprehensive results, with more flexibility than ever before!
The PEAKS Team
Bioinformatics Solutions Inc.