Kim, W. J., Crosse, E. I., De Neef, E., Etxeberria, I., Sabio, E. Y., Wang, E., ... & Abdel-Wahab, O. (2025). Mis-splicing-derived neoantigens and cognate TCRs in splicing factor mutant leukemias. Cell. doi:10.1016/j.cell.2025.03.047
Translation dysregulation in cancer as a source for targetable antigens
Weller, C., Bartok, O., McGinnis, C. S., Palashati, H., Chang, T. G., Malko, D., ... & Samuels, Y. (2025). Translation dysregulation in cancer as a source for targetable antigens. Cancer cell, 43(5), 823-840. doi:10.1016/j.ccell.2025.03.003
Maximizing Immunopeptidomics-Based Bacterial Epitope Discovery by Multiple Search Engines and Rescoring
Willems, P., Thery, F., Van Moortel, L., De Meyer, M., Staes, A., Gul, A., ... & Impens, F. (2025). Maximizing immunopeptidomics-based bacterial epitope discovery by multiple search engines and rescoring. Journal of Proteome Research, 24(4), 2141-2151. doi:10.1021/acs.jproteome.4c00864
Precise mycobacterial species and subspecies identification using the PEP-TORCH peptidome algorithm
Mycobacterial infections remain a major global health concern, requiring fast and accurate identification for effective treatment.
HLA I immunopeptidome of synthetic long peptide pulsed human dendritic cells for therapeutic vaccine design
Synthetic long peptides (SLPs) are a promising candidate for therapeutic vaccine due to its characteristics. To design an effective SLP-based vaccine, knowing the presented immunopeptidome after the vaccine is very important.
Impact of Bioinformatics Search Parameters for Peptides’ Identification and Their Post-Translational Modifications: A Case Study of Proteolysed Gelatines from Beef, Pork, and Fish
Learn how PEAKS is being used in agrifood studies for peptide and PTM identification.
Comprehensive characterization and detection of nut allergens in bakery foods using Q-TOF mass spectrometry and bioinformatics
Learn how mass spectrometry shows promise, allowing precise allergen detection.
TOF IMS mass spectrometry-based immunopeptidomics refines tumor antigen identification
Learn how immunotherapy relies on tumour antigens to stimulate anti-tumour T cell responses, and emphasises the need to identify exclusive tumour surface antigens.
Proteomic and toxicological characterization of the venoms of the most enigmatic group of rattlesnakes: The long-tailed rattlesnakes
Learn how this study further our understanding of rattlesnake venom evolutionary and how this can aid in development of effective antivenoms.
Some structural features of the peptide profile of myelin basic protein-hydrolyzing antibodies in schizophrenic patients
Learn how this study sheds light on the mechanism behind IgG's catalytic nature in acute schizophrenia cases.