The Pacific oyster is a major seafood around the world and it is important to understand the effect of heating on proteins of this aquatic species. Learn how LC-MS/MS was used and how studies on food processing can improve the safety of food and reduce health-related costs.

Lactylation is a post translation modification (PTM) derived from lactate and here, researchers have shown that lactylation is a widespread PTM that is not restricted to histones and have developed a sensitive and validated method for lactylation identification by liquid chromatography–tandem mass spectrometry (LC–MS/MS).

Glioblastoma (GBM) is the most common and malignant brain tumour. Learn how LC-MS/MS is proving to be a beneficial method to understanding of brain extracellular matrix changes in GBM pathogenesis and discovery of novel makers and therapeutic targets.

Alterations in the matrisome, including collagens, glycoproteins, and proteoglycans, have been shown to be associated with neurodegenerative disorders. Here researchers investigated the alterations in the expression and modification of the matrisome.

Though there appears to be both genetic and environmental factors that influence the development of Myopia or nearsightedness, the precise mechanism remains unknown. In this study the research group aimed to analyze the exosomal protein profile of the aqueous humor (AH) of myopia patients to provide insight for the diagnosis, clinical treatment and prognosis of myopia.

Immunotherapy, like Immune checkpoint blockade (ICB), has been widely used with chemotherapy to improve cancer treatment. Since cannabis is used to treat nausea caused by chemotherapy, Xiong et al. studied if THC interferes with ICB treatment through the cannabinoid receptor 2 (CNR2) pathway.

Small open reading frames (smORF) located on long noncoding RNAs (lncRNAs) have recently been shown to encode functional microproteins that play important roles in different cellular processes. This study investigated the functions and evolution of smORFs present in lncRNAs in a moss species.

High blood pressure is a common chronic medical condition and a major risk factor in developing cardiovascular disease. The angiotensin-I-converting enzyme (ACE) plays a critical role in controlling blood pressure, and ACE inhibitors are a class of medication in use to treat high blood pressure. Learn how Su et al., studied marine organisms, Takifugu flavidus, to reveal a novel ACE inhibitory peptide.

Alzheimer’s disease (AD) is a prevalent age-related neurodegenerative disorder affecting millions of people worldwide. Little is known about the early molecular changes that initiate plaque and tangle formation. Learn how Salivary Proteomics is used to detect biomarkers for early Dementia conversion.

Understanding what causes a stem cell to enter the cell cycle, and what happens when it does, is key to determining how we can maximise the therapeutic potential of these cells to repair injured tissues or treat diseases. Here, Zeng et al., use LC-MS/MS to study the activation of a particular type of stem cell, Satellite cells (SC), that have the potential to repair damaged skeletal muscle.