ProteoformX 1.5.1 is Here!
We are excited to announce new updates to ProteoformX, introducing powerful new features across Intact, Top-down, and Bottom-up analyses. Customisable workflows across each module to fit your unique research needs. CFR compliance readiness ensures data integrity, security, and audit preparation in any clinical or biopharmaceutical setting.
With fully integrated analytical workflows spanning the breadth of proteoform-level characterisation, from cutting-edge proteomics research to biopharmaceutical analysis, ProteoformX continues to redefine what is possible.
Intact Mass Analysis
- Use high precision mass deconvolution of protein mixtures with detailed glycoforms and PTM annotations, reporting detectable proteoforms with corresponding mass and retention time.
- Versatile visualisation options, including Heat Map view for monitoring proteoform intensity changes. Proteoform Manager for defining proteoform details, residues, and modifications.
- NEW! Batch search and Compare Analysis functions give users a streamlined interface to evaluate and compare results for QC or discovery of modifications introduced during engineering.
- NEW! Redesigned manual annotation tool delivers a significantly expanded feature set for in-depth spectral analysis of target molecular mass, delta masses between base peaks, and modification candidates.
Top-Down Search
- Achieve a comprehensive understanding of individual proteoforms by integrating Top-down and Bottom-up data analyses to balance broad screening with precise molecular detail, enabling confident sequence validation and resolution of PTM co‑occurrence.
- NEW! View Proteoform Networks showing the relationship between different proteoforms generated by one gene, including the mass shifts for the modified proteoforms.
- NEW! Add confidence level to evaluate the confidence in proteoform identification. Bottom-up analysis complements top-down data by generating peptide-level evidence, which can provide additional sequence coverage and support PTM localization.
Peptide Mapping
- Use Bottom-up proteomics to characterise protein sequences, post-translational modifications, and sequence variants at the peptide level.
- NEW! Hierarchical peptide visualisation: Organises peptide mapping results around fully digested backbone peptides, grouping related modified and variant forms together to streamline sequence coverage assessment, modification characterization, and cross-sample quantitation.
Ready to see what’s possible with ProteoformX 1.5.1?
Check out the full list of features and enhancements on our launch page.
Discover deeper insights, versatile visualisations, and comprehensive results, with more flexibility than ever before!
The PEAKS Team
Bioinformatics Solutions Inc.