Scanning DIA on the ZenoTOF 8600 system enables ultra-sensitive and quantitative proteomics from single cells to post-translational modifications in a compact platform

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On 2026-03-192026-03-19By In Featured User Publications

PEAKS Studio 13.1 shows off its application prowess in working with the new ZenoTOF 8600!

We are thrilled to see PEAKS Studio 13.1 be featured in the paper “Scanning DIA on the ZenoTOF 8600 system enables ultra-sensitive and quantitative proteomics from single cells to post-translational modifications in a compact platform” and used to benchmark the proteomics performance of the state-of-the-art platform.

In this paper, Heymann et al., led by Dr. Matthias Mann, demonstrate the effectiveness of the ZenoTOF 8600 by benchmarking its performance across a broad range of proteomics applications, including  high-throughput and single-cell proteome coverage, quantitative accuracy, targeted sensitivity, and post‑translational modification analysis.

Using scanning quadrupole DIA (ZT Scan DIA), the authors show improved peptide and protein identifications and quantitative reproducibility compared with conventional DIA, while demonstrating robust performance when using PEAKS Studio 13.1 across applications ranging from ultra‑high‑throughput bulk proteomics and single‑cell analysis to low‑attomole targeted quantitation and disease‑relevant phosphorylation profiling.

The PEAKS team is honoured to be part of this rigorous evaluation of the ZenoTOF 8600, with PEAKS Studio 13.1 serving as a reliable benchmark for ultra-sensitive and quantitative proteomics. At BSI, we remain committed to advancing accurate, real‑time proteomics analysis through deep‑learning–powered solutions that enable researchers to fully realise the potential of next‑generation instrumentation.

Interested in exploring the extensive capabilities of PEAKS Studio? Reach out to us today!

Read the full article here: Heymann, T., Oliinyk, D., Henneberg, L., Lorenz, M.B., Eikmeier, N., Thielert, M., Oeller, M.,  Grauvogel, L., Sitron, C.S., Loyd, B., Le Blanc, Y., Bloomfield, N., Batruch, I., Causon, J., Chelur, A., Ivosev, G., Tran, K., Talamantes, T., Schneider, B., Castro-Perez, J., Mann, M. (2026). Scanning DIA on the ZenoTOF 8600 system enables ultra-sensitive and quantitative proteomics from single cells to post-translational modifications in a compact platform. bioRxiv. doi:10.64898/2026.03.12.711261