Hardesty, J.E., et al. Hepatic signalling disruption by pollutant Polychlorinated biphenyls in steatohepatitis. Cellular Signalling. 53, 132-139. 1/1/2019.
PCBs are signal disrupting chemicals that promote secondary necrosis through affecting a myriad of liver processes including metabolism and cellular maintenance. PCB exposure, particularly with interaction with a HFD greatly down-regulates the hepatic kinome. More data are needed on signalling disruption and its impact on liver health.