Accelerating Personalized Cancer Vaccines with LC-MS Immunopeptidomics and PEAKS Personalized cancer vaccines are transforming oncology by targeting tumor-specific neoantigens –...
Mis-splicing-derived neoantigens and cognate TCRsin splicing factor mutant leukemias
Effective immunotherapy for acute myeloid leukemia (AML) currently relies primarily on neoantigens derived from somatic mutations. However, these can sometimes...
Translation dysregulation in cancer as a source for targetable antigens
Exploring Mistranslation as a Source of Neoantigens in Cancer Immunotherapy The importance of neoantigens in cancer immunotherapies has been underscored...
Maximizing Immunopeptidomics-Based Bacterial Epitope Discovery by Multiple Search Engines and Rescoring
Unlocking Bacterial Epitope Discovery: How Rescoring and PEAKS Deep Learning Boost Immunopeptidomics Antimicrobial resistance is a serious and growing global...
Precise mycobacterial species and subspecies identification using the PEP-TORCH peptidome algorithm
Mycobacterial infections remain a major global health concern, requiring fast and accurate identification for effective treatment.
HLA I immunopeptidome of synthetic long peptide pulsed human dendritic cells for therapeutic vaccine design
Synthetic long peptides (SLPs) are a promising candidate for therapeutic vaccine due to its characteristics. To design an effective SLP-based vaccine, knowing the presented immunopeptidome after the vaccine is very important.
Impact of Bioinformatics Search Parameters for Peptides’ Identification and Their Post-Translational Modifications: A Case Study of Proteolysed Gelatines from Beef, Pork, and Fish
Learn how PEAKS is being used in agrifood studies for peptide and PTM identification.
Comprehensive characterization and detection of nut allergens in bakery foods using Q-TOF mass spectrometry and bioinformatics
Learn how mass spectrometry shows promise, allowing precise allergen detection.
TOF IMS mass spectrometry-based immunopeptidomics refines tumor antigen identification
Learn how immunotherapy relies on tumour antigens to stimulate anti-tumour T cell responses, and emphasises the need to identify exclusive tumour surface antigens.
Proteomic and toxicological characterization of the venoms of the most enigmatic group of rattlesnakes: The long-tailed rattlesnakes
Learn how this study further our understanding of rattlesnake venom evolutionary and how this can aid in development of effective antivenoms.