Chang, Deborah, et al. “Data-Independent Acquisition Mass Spectrometry for Site-Specific Glycoproteomics Characterization of SARS-CoV-2 Spike Protein.” Analytical and Bioanalytical Chemistry,...
Visualizing transfer of microbial biomolecules by outer membrane vesicles in microbe-host-communication in vivo
Bittel, Miriam, et al. “Visualizing Transfer of Microbial Biomolecules by Outer Membrane Vesicles in Microbe‐host‐communication in Vivo.” Journal of Extracellular...
Human plasma IgG1 repertoires are simple, unique, and dynamic
Bondt, Albert, et al. “Human Plasma IgG1 Repertoires Are Simple, Unique, and Dynamic.” SSRN Electronic Journal, Elsevier BV, 2020. Crossref,...
Proteomics reveal cap-dependent translation inhibitors remodel the translation machinery and translatome
In a recent study by Ho et al, LC-MS/MS was used to examine the influence of a rocaglate on the cellular proteome & translatome to study the effects of these drugs on the process of protein production. Learn more & how translational remodeling effects drug’s potency
Transcriptome Profiling of the Pacific Oyster Crassostrea gigas Visceral Ganglia over a Reproduction Cycle Identifies Novel Regulatory Peptides
Using 4D proteomics, Realis-Doyelle, E., et al. were able to identify 25 neuropeptide precursors involved in the regulation of reproduction in Pacific oysters. By using PEAKS IMS, the researchers were able to take advantage of the 4th-dimension of data generated by the timsTOF Pro.
Murine neuronatin deficiency is associated with a hypervariable food intake and bimodal obesity
To study how a change in genetic information, like neuronatin deficiency, has on food intake and body mass, Ciminoet et al. used LC-MS/MS to study the peptides of pancreatic hormones in Nnat deficient and wildtype mice. Learn about this study and how this approach can be used for other studies, like hormone processing, receptor sensitivity, etc.
Epigenetic inactivation of the autophagy–lysosomal system in appendix in Parkinson’s disease
The link between gut & brain health is a target of interest for Parkinson’s disease (PD) research. In this paper, Gordevicius et al, use multi-molecular methods to study PD pathology from epigenetic changes in DNA & altered transcription, to the resulting modified protein abundance.
In vitro metabolism of synthetic Elabela/Toddler (ELA-32) peptide in human plasma and kidney homogenates analyzed with mass spectrometry and validation of endogenous peptide quantification in tissues by ELISA
Studies about cardiovascular diseases have shown the Elabela/Toddler (ELA) ligand to be a beneficial apelin Rc. agonist. In a recent paper, Nyimanu et al. used LC-MS/MS methods to examine how the different forms of ELA individually impact signaling networks in the human body.
A complete workflow for discovering small bioactive peptides in foods by LC-MS/MS: A case study on almonds
In our food and supplements, we see new functional foods and nutraceuticals with new claims everyday. But do these compounds show any bioactivity to support these claims? Huang et al show Mass spec can be a great tool to study these compound.
Monitoring the M-protein of multiple myeloma patients treated with a combination of monoclonal antibodies: the laboratory solution to eliminate interference
In this study, Noori et al show that MS-based MRD monitoring is over 15-fold more sensitive than conventional diagnostic measures. More importantly, MS-based MRD monitoring with PEAKS de novo sequencing can be used with heterogeneous patient populations, and does not have to be adapted when novel t-mAb are approved for use in patients.