Utilising Machine Learning Model, DeepNovo, to advance Personalised Cancer Treatments

Bioinformatics Solutions Inc. (BSI) is proud to share exciting work from owner and founder, Prof. Dr. Ming Li, and Senior Research Scientist, Dr. Hieu Tran, in the advancements for personalised cancer treatment. Their work in machine learning was recently highlighted by the University of Waterloo’s press which quickly summarised the concept behind cancer immunotherapy and the research that Prof. Dr. Li and Dr. Tran have accomplished, to further the development of this type of treatment. Compared to other types of cancer treatments, cancer immunotherapy is personalised for each specific individual by using the patient’s own immune system to fight the cancer. In a statement from Prof. Dr. Li, “Every patient is different and every cancer is different, so cancer treatment shouldn’t be the same for all. Treatment should be tailored to the patient, and that’s what our personalised machine learning model allows us to do.” By using machine learning, Prof. Dr. Li and Dr. Tran are able to analyse known patient immunopeptidomes to train algorithms, such as their published recurrent neural-network model, DeepNovo, to predict the mutated, cancer-presenting peptides known as neoantigens to develop cancer vaccines personalised to each patient. To learn more about this work and other exciting news from the university, check out the following link: https://uwaterloo.ca/daily-bulletin/2021-04-21#using-machine-learning-to-develop-personalized-cancer-treatment.

If you want to read the Machine Learning publications this article is based on please find the DeepNovo, DeepNovo-DIA and other papers on our website, https://www.bioinfor.com/bsi-publications/.

Prof. Dr. Ming Li is a university professor at the Cheriton School of Computer Science, University of Waterloo. He is also currently the Canada Research Chair in Bioinformatics which he has held since 2002. Having found BSI in March 2000, Prof. Dr. Li is an active and important contributor in the company’s research and developments.

Dr. Hieu Tran is an Adjunct Assistant Professor at the Cheriton School of Computer Science. His expertise in computer science allows him to contribute ground-breaking research to the industry and state-of-art developments here, at BSI.