A Complete Software Suite for de novo Sequencing and Predicting the Immunogenicity of Class 1 and Class 2 Neoantigens

Tran, N., et al. A complete software suite for de novo sequencing and predicting the immunogenicity of class 1 and class 2 neoantigens. HUPO. 09/18/2023.

Purpose: To develop an automated software suite to accelerate the identification of immunogenetic immunopeptides.
Methods: AI-based de novo sequencing, database search and immunogenetic prediction were integrated for neoantigen identification.
Results: A software suites, PEAKS 11 and DeepImmu, were provided for immunopeptidomics with high sensitivity and accuracy.